Readings

Translational Research

  1. Pound P, Ritskes-Hoitinga M. Is it possible to overcome issues of external validity in preclinical animal research? Why most animal models are bound to fail. Journal of translational medicine. 2018 Dec;16(1):1-8.
  2. Schmidt‐Pogoda A, Bonberg N, Koecke MH, Strecker JK, Wellmann J, Bruckmann NM, Beuker C, Schäbitz WR, Meuth SG, Wiendl H, Minnerup H. Why most acute stroke studies are positive in animals but not in patients: a systematic comparison of preclinical, early phase, and phase 3 clinical trials of neuroprotective agents. Annals of neurology. 2020 Jan;87(1):40-51.
  3. Austin CP. Opportunities and challenges in translational science. Clinical and Translational Science. 2021 Sep;14(5):1629-47.

Reproducibility in Science

  1. Begley CG, Ioannidis JP. Reproducibility in science: improving the standard for basic and preclinical research. Circulation research. 2015 Jan 2;116(1):116-26.
  2. Begley CG, Ellis LM. Raise standards for preclinical cancer research. Nature. 2012 Mar;483(7391):531-3.
  3. Errington TM, Denis A, Perfito N, Iorns E, Nosek BA. Reproducibility in Cancer Biology: Challenges for assessing replicability in preclinical cancer biology. eLife. 2021 Dec 7;10:e67995.

Reporting in Pre-clinical sciences

  1. [Percie du Sert N, Ahluwalia A, Alam S, Avey MT, Baker M, Browne WJ, Clark A, Cuthill IC, Dirnagl U, Emerson M, Garner P. Reporting animal research: Explanation and elaboration for the ARRIVE guidelines 2.0. PLoS biology. 2020 Jul 14;18(7):e3000411.]
  2. Avey MT, Moher D, Sullivan KJ, Fergusson D, Griffin G, Grimshaw JM, Hutton B, Lalu MM, Macleod M, Marshall J, Mei SH. The devil is in the details: incomplete reporting in preclinical animal research. PLoS One. 2016 Nov 17;11(11):e0166733.
  3. Serghiou S, Contopoulos-Ioannidis DG, Boyack KW, Riedel N, Wallach JD, Ioannidis JP. Assessment of transparency indicators across the biomedical literature: How open is open?. PLoS biology. 2021 Mar 1;19(3):e3001107.

Heterogeneity

  1. Usui T, Macleod MR, McCann SK, Senior AM, Nakagawa S. Meta-analysis of variation suggests that embracing variability improves both replicability and generalizability in preclinical research. PLoS biology. 2021 May 19;19(5):e3001009.
  2. Voelkl B, Vogt L, Sena ES, Würbel H. Reproducibility of preclinical animal research improves with heterogeneity of study samples. PLoS biology. 2018 Feb 22;16(2):e2003693.
  3. Richter SH. Systematic heterogenization for better reproducibility in animal experimentation. Lab animal. 2017 Sep;46(9):343-9.

Sex as Biological Variable

  1. Garcia-Sifuentes Y, Maney DL. Reporting and misreporting of sex differences in the biological sciences. eLife 2021;10:e70817
  2. Woitowich NC, Beery A, Woodruff T. Meta-research: a 10-year follow-up study of sex inclusion in the biological sciences. eLife. 2020 Jun 9;9:e56344.
  3. Beery AK. Inclusion of females does not increase variability in rodent research studies. Current opinion in behavioral sciences. 2018 Oct 1;23:143-9.